Association of Subcortical Structural Shapes With Tau, Amyloid, and Cortical Atrophy in Early-Onset and Late-Onset Alzheimer’s Disease

Frontiers in Aging Neuroscience

Joon-Kyung Seong¹  Young Noh²  Kee Hyung Park³  Sang-Yoon Lee⁵  Seongho Seo⁵  Jae Myeong Kang⁶  Duk L. Na⁷  Ha-Eun Seo⁸  Eun-Chong Lee⁹ 

[1] Department of Artificial Intelligence, Korea University, Seoul, South Korea;Department of Health Science and Technology, GAIHST, Gachon University, Incheon, South Korea;Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea;Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;Department of Neuroscience, College of Medicine, Gachon University, Incheon, South Korea;Department of Psychiatry, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea;Neuroscience Center, Samsung Medical Center, Seoul, South Korea;Neuroscience Research Institute, Gachon University, Incheon, South Korea;School of Biomedical Engineering, Korea University, Seoul, South Korea;

关键词: Alzheimer’s disease;    subcortical shape analysis;    tau;    amyloid;    cortical thickness;    positron emission tomography;   

DOI  :  10.3389/fnagi.2020.563559

来源: DOAJ

【 摘 要 】

The objectives of this study were to compare the topographical subcortical shape and to investigate the effects of tau or amyloid burden on atrophic patterns in early onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD). One hundred and sixty-one participants (53 EOAD, 44 LOAD, 33 young controls, and 31 older controls) underwent [18F]THK5351 positron emission tomography (PET), [18F]flutemetamol (FLUTE) PET, and 3T MRI scans. We used surface-based analysis to evaluate subcortical structural shape, permutation-based statistics for group comparisons, and Spearman’s correlations to determine associations with THK, FLUTE, cortical thickness, and neuropsychological test results. When compared to their age-matched controls, EOAD patients exhibited shape reduction in the bilateral amygdala, hippocampus, caudate, and putamen, while in LOAD patients, the bilateral amygdala and hippocampus showed decreased shapes. In EOAD, widespread subcortical shrinkage, with less association of the hippocampus, correlated with THK retention and cortical thinning, while in LOAD patients, subcortical structures were limited which had significant correlation with THK or mean cortical thickness. Subcortical structural shape showed less correlation with FLUTE global retention in both EOAD and LOAD. Multiple cognitive domains, except memory function, correlated with the bilateral amygdala, caudate, and putamen in EOAD patients, while more restricted regions in the subcortical structures were correlated with neuropsychological test results in LOAD patients. Subcortical structures were associated with AD hallmarks in EOAD. However, the correlation was limited in LOAD. Moreover, relationship between subcortical structural atrophy and cognitive decline were quite different between EOAD and LOAD. These findings suggest that the effects of Alzheimer’s pathologies on subcortical structural changes in EOAD and LOAD and they may have different courses of pathomechanism.

【 授权许可】

Unknown