Biochanin A Ameliorates Arsenic-Induced Hepato- and Hematotoxicity in Rats

Molecules

Abdulkadhar Mohamed Jalaludeen¹  Woo Tae Ha¹  Ran Lee¹  Jin Hoi Kim¹  Jeong Tae Do¹  Chankyu Park¹  Young Tae Heo¹  Won Young Lee²  Hyuk Song¹ 

[1] Department of Animal Biotechnology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Korea;Division of Food Bioscience, College of Biomedical and Health Science, Konkuk University, Chung-ju 380-701, Korea;

关键词: arsenic;    biochanin A;    lipid peroxidation;    reactive oxygen species;    selenium;   

DOI  :  10.3390/molecules21010069

来源: mdpi

【 摘 要 】

Biochanin A (BCA) is a natural organic compound of the phytoestrogenic isoflavone class that has antioxidant and metal chelator properties in the presence of transition metal ions, however, its efficacy in animal models is still obscure. Therefore, the objective of this study was to investigate the protective effects of BCA against arsenic-induced hepatic injury and hematotoxicity in rats. The results suggest that arsenic intoxicated rats showed significantly higher levels of plasma hepatic markers than normal control rats. Furthermore, an increase in lipid peroxidation with depletion of reduced glutathione (GSH) and activities of superoxide dismutase (SOD) and catalase (CAT) occurred in the livers of rats exposed to arsenic. Administration of BCA (20 mg/kg·bw/day) and selenium (3 mg/kg·bw/day) resulted in a significant reversal of hepatic and oxidative stress markers in arsenic-intoxicated rats. A low dose of BCA (10 mg/kg·bw/day) did not show any preventive effect, while a high dose of BCA (40 mg/kg·bw/day) partially prevented all hepatotoxicity events. These biochemical perturbations were supported by histopathological observations of the liver. Our results suggest that administration of BCA (20 mg/kg·bw/day) attenuated the arsenic hepatotoxicity, a property that could contribute to the therapeutic approaches for chronic liver diseases.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.