International Journal of Environmental Research and Public Health | |
UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides † | |
Qingsu Xia3  Jun J. Yin2  Yuewei Zhao3  Yuh-Sen Wu1  Yu-Qui Wang3  Liang Ma3  Shoujun Chen3  Xin Sun4  Peter P. Fu3  | |
[1] Hung Kuang University, Sha-Lu, Taichung, 443, Taiwan; E-Mail:;Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA; E-Mail:;National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; E-Mails:;National Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China; E-Mail: | |
关键词: nitro-polycyclic aromatic hydrocarbons; photoiradiation; UVA light; reactive oxygen species; lipid peroxidation; | |
DOI : 10.3390/ijerph10031062 | |
来源: mdpi | |
【 摘 要 】
Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which nitro-PAHs induce genotoxicity. Although the metabolic activation of nitro-PAHs leading to toxicological activities has been well studied, the photo-induced activation of nitro-PAHs has seldom been reported. In this paper, we report photo-induced lipid peroxidation by 19 nitro-PAHs. The results indicated that all but two of the nitro-PAHs can induce lipid peroxidation. Mechanistic studies suggest that lipid peroxidation by nitro-PAHs is mediated by free radicals generated in the reaction. There was no structural correlation between the nitro-PAHs and their ability to induce lipid peroxidation upon UVA irradiation, or between the HOMO-LUMO gap and the ability to cause lipid peroxidation. Most of the nitro-PAHs are less potent in terms of causing lipid peroxidation than their parent PAHs. The lack of correlation is attributed to the complex photophysics and photochemistry of the nitro-PAHs and the yield of reactive oxygen species (ROS) and other factors.
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
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