UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides †

International Journal of Environmental Research and Public Health

Qingsu Xia³  Jun J. Yin²  Yuewei Zhao³  Yuh-Sen Wu¹  Yu-Qui Wang³  Liang Ma³  Shoujun Chen³  Xin Sun⁴  Peter P. Fu³ 

[1] Hung Kuang University, Sha-Lu, Taichung, 443, Taiwan; E-Mail:;Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA; E-Mail:;National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; E-Mails:;National Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China; E-Mail:

关键词: nitro-polycyclic aromatic hydrocarbons;    photoiradiation;    UVA light;    reactive oxygen species;    lipid peroxidation;   

DOI  :  10.3390/ijerph10031062

来源: mdpi

【 摘 要 】

Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which nitro-PAHs induce genotoxicity. Although the metabolic activation of nitro-PAHs leading to toxicological activities has been well studied, the photo-induced activation of nitro-PAHs has seldom been reported. In this paper, we report photo-induced lipid peroxidation by 19 nitro-PAHs. The results indicated that all but two of the nitro-PAHs can induce lipid peroxidation. Mechanistic studies suggest that lipid peroxidation by nitro-PAHs is mediated by free radicals generated in the reaction. There was no structural correlation between the nitro-PAHs and their ability to induce lipid peroxidation upon UVA irradiation, or between the HOMO-LUMO gap and the ability to cause lipid peroxidation. Most of the nitro-PAHs are less potent in terms of causing lipid peroxidation than their parent PAHs. The lack of correlation is attributed to the complex photophysics and photochemistry of the nitro-PAHs and the yield of reactive oxygen species (ROS) and other factors.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.