Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo

International Journal of Clinical and Experimental Pathology

Hong-Ying Liang¹  Li-Hua Sun¹  Yu-Jiao Cai¹  Daniel H Teitelbaum¹  Hua Yang¹  Wen-Sheng Wang¹ 

关键词: Keratinocyte growth factor;    interleukin-7;    ischemia/reperfusion;    mouse;    epithelial cells;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Epithelial cell (EC)-derived Interleukin-7 (IL-7) plays a crucial role in control of neighboring intestinal intraepithelial lymphocytes (IEL) development and homeostasis, and IEL derived keratinocyte growth factor (KGF) promotes intestinal epithelial growth, which was regulated by EC-derived IL-7. On this basis, we hypothesize that there is a crosstalk between IELs and ECs, and KGF could regulate the EC-derived IL-7 expression, which should be associated with the protective effects by KGF on intestinal injury.

【 授权许可】

Unknown