MicroRNA-7 inhibits metastasis and invasion through targeting focal adhesion kinase in cervical cancer

International Journal of Clinical and Experimental Medicine

Jing Qian¹  Liulin Zhou¹  Yanqing Zhang¹  Jing Liu¹  Jishi Yang¹  Yaoyao Li¹  Yu Zhang¹  Chenghai Wang¹  Zhenfeng Hao¹  Xiaoyun Dong¹ 

关键词: microRNA;    miR-7;    focal adhesion kinase;    cervical cancer;    metastasis;    invasion;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

MicroRNAs (miRNAs) are aberrantly expressed in cervical cancer. miR-7 has been demonstrated to function as both an oncogene and a tumor suppressor in some types of human cancers. In the present study, miR-7 was significantly downregulated in cervical cancer, especially metastatic tumors. Ectopic expression of miR-7 significantly inhibited metastasis and invasion in Hela and C33A cells. Upregulated miR-7 significantly suppressed focal adhesion kinase (FAK) at transcriptional and translational levels. Furthermore, the level of FAK was negatively correlated with miR-7 in cervical cancer tissues. In conclusion, miR-7 inhibited the metastasis and invasion of cervical cancer at least partially through targeting FAK. The findings of this study provide novel insight with potential therapeutic applications for the treatment of metastatic cervical cancer.

【 授权许可】

Unknown