International Journal of Clinical and Experimental Medicine | |
MicroRNA-7 inhibits metastasis and invasion through targeting focal adhesion kinase in cervical cancer | |
Jing Qian1  Liulin Zhou1  Yanqing Zhang1  Jing Liu1  Jishi Yang1  Yaoyao Li1  Yu Zhang1  Chenghai Wang1  Zhenfeng Hao1  Xiaoyun Dong1  | |
关键词: microRNA; miR-7; focal adhesion kinase; cervical cancer; metastasis; invasion; | |
DOI : | |
学科分类:医学(综合) | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
MicroRNAs (miRNAs) are aberrantly expressed in cervical cancer. miR-7 has been demonstrated to function as both an oncogene and a tumor suppressor in some types of human cancers. In the present study, miR-7 was significantly downregulated in cervical cancer, especially metastatic tumors. Ectopic expression of miR-7 significantly inhibited metastasis and invasion in Hela and C33A cells. Upregulated miR-7 significantly suppressed focal adhesion kinase (FAK) at transcriptional and translational levels. Furthermore, the level of FAK was negatively correlated with miR-7 in cervical cancer tissues. In conclusion, miR-7 inhibited the metastasis and invasion of cervical cancer at least partially through targeting FAK. The findings of this study provide novel insight with potential therapeutic applications for the treatment of metastatic cervical cancer.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912140864548ZK.pdf | 1177KB | download |