Value of non-coding RNAs to assess lymph node status in cervical cancer

Frontiers in Oncology

Oncology

Yannick Marie¹  Yohann Dabi²  Emile Daraï²  Amelia Favier²  Cyril Touboul²  Clément Ferrier²  Sofiane Bendifallah²  Léo Razakamanantsoa³  Stéphane Suisse⁴ 

[1] Gentoyping and Sequencing core facility, iGenSeq, Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle (ICM), Hôpital Pitié-Salpêtrière, Paris, France;Sorbonne University, Department of Obstetrics and Reproductive Medicine, Hôpital Tenon, Paris, France;Clinical Research Group (GRC) Paris 6: Centre Expert Endométriose (C3E), Sorbonne University (GRC6 C3E SU), Paris, France;Sorbonne University, Inserm UMR S 938, Centre de recherche de saint Antoine (CRSA), Hôpital Saint Antoine, Paris, France;Department of Radiology imaging and Interventional speciality imaging, Tenon Hospital, Paris, France;Ziwig, Lyon, France;

关键词: cervical cancer;    lymph node metastasis;    non-coding RNA;    microRNA;    long non coding RNA;    biomarker;   

DOI  :  10.3389/fonc.2023.1144672

 received in 2023-01-14, accepted in 2023-04-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cervical cancer (CC) is the fourth cancer in women and is the leading cause of cancer death in 42 countries. Lymph node metastasis is a determinant prognostic factor, as underlined in the latest FIGO classification. However, assessment of lymph node status remains difficult, despite the progress of imaging such as PET-CT and MRI. In the specific setting of CC, all data underlined the need for new biomarkers easily available to assess lymph node status. Previous studies have underlined the potential value of ncRNA expression in gynecological cancers. In this review, we aimed to evaluate the contribution of ncRNAs in tissue and biofluid samples to determine lymph node status in CC with potential impact on both surgical and adjuvant therapies. In tissue samples, our analysis found that there are arguments to support the role of ncRNAs in physiopathology, differential diagnosis from normal tissue, preinvasive and invasive tumors. In biofluids, despite small studies especially concerning miRNAs expression, promising data opens up new avenue to establish a non-invasive signature for lymph node status as well as a tool to predict response to neo- and adjuvant therapies, thus improving management algorithm of patients with CC.

【 授权许可】

Unknown   
Copyright © 2023 Dabi, Favier, Razakamanantsoa, Suisse, Marie, Touboul, Ferrier, Bendifallah and Daraï