Effects of cigarette smoke on aerobic capacity and serum MDA content and SOD activity of animal

International Journal of Clinical and Experimental Medicine

Yi Wang¹  Li-Jun Zheng¹  Xiao-Zhi Ma¹  Xin-Ping Zhao¹  Jian-Ping Hu¹ 

关键词: Cigarette;    aerobic exercise;    superoxide dismutase (SOD);    malonaldehyde (MDA);    mouse;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Objective: Study the effects of cigarette smoke on aerobic capacity, serum MDA content and SOD activity of animal. Methods: 60 male mice are randomly divided into mild smoking group, heavy smoking group, and control group, and the exhausted swimming time, serum SOD activity and MDA content of the three groups of mice are respectively measured before and after the experiment. Results: After the experiment, the exhausted swimming time for the control group, mild smoking and heavy smoking groups is respectively 276.57 min, 215.57 min and 176.54 min, and the serum SOD activities for the three objects are 216.46 U/mL, 169.16 U/mL and 154.91 U/mL, and the MDA contents are respectively 16.41 mol/mL, 22.31 mol/mL and 23.55 mol/mL. According to the comparison, it is found that compared with the control group and pre-intervention, the exhausted swimming time and serum SOD activity of the smoking group decreases obviously, and its MDA content rises sharply, and the difference has significance (P < 0.05), moreover, the heavy smoking group has more obvious changes than the mild group. Conclusion: Cigarette smoke can significantly weaken the aerobic capacity and fatigue resistance of mice, and the more the smoking time is longer, the more the harmful effect is more serious, this is related to the SOD activity drops and MDA content rises due to smoking.

【 授权许可】

Unknown