Coeloglossum viride var. bracteatum extract protects against amyloid toxicity in rat prefrontal cortex neurons

International Journal of Clinical and Experimental Medicine

Yan Zhang¹  Jia Cui¹  Xiao-Yan Qin¹ 

关键词: CE;    Alzheimer's disease;    Amyloid β;    Coeloglossum viride var.bracteatum;    traditional Chinese medicine;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

CE is the extract from Coeloglossum viride var.bracteatum, a plant widely used as a traditional medicine in the Southwest China, such as Tibet. The effects of CE against amyloid toxicity in cell culture were examined in the present study. The results indicate that CE can protect against amyloid β (Aβ)_25-35-induced cytotoxicity in rat primary prefrontal cortex neurons. Bcl₂ and Csp3 activation may be involved in CE protection. CE could be a promising candidate for amyloid-based Alzheimer's disease (AD) prevention or therapy.

【 授权许可】

Unknown