The effects of Fhit on tumorigenesis after multi-exposure to low-dose radiation

International Journal of Clinical and Experimental Medicine

Lin Lu¹  Siyuan Wen¹  Ya Wang¹  Xiaoyan Yu¹ 

关键词: Fhit;    low dose;    ionizing radiation;    tumorigenesis;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Low-dose (≤ 0.1 Gy) radiation could reduce high-dose induced damage including tumorigenesis. However, it remains unclear whether multi-exposure to low-dose radiation at a high dose rate has any risk for increasing tumorigenesis, and whether Fhit plays any role in the process. The purpose of this study is to investigate the effects of multi-exposure to low-dose radiation at a high dose rate on tumorigenesis, and the role of Fhit in it. We irradiated Fhit^+/+ and Fhit^-/- mice with 1 Gy/1 or 0.1 Gy × 10 exposures at a dose rate of 1 Gy/min, sacrificed the mice at 1.5 years after radiation and observed multi-organ tumorigenesis. The results showed that although the spontaneous tumorigenesis in these mice was relatively high, 1 Gy/1-exposure dramatically increased the tumorigenesis including lung and liver tumor. Fhit^-/- mice showed more tumorigenesis than Fhit^+/+ mice after 1 Gy/1-exposure. However, 0.1 Gy × 10 exposures did not increase tumorigenesis, and there was no statistical difference in tumorigenesis between Fhit^+/+ mice and Fhit^-/- mice following 0.1 Gy × 10 exposures. Our results suggest that 0.1 Gy, even after multiple exposures, does not increase tumorigenesis, and Fhit could prevent high-dose radiation-induced tumors but has no effect in a low-dose environment.

【 授权许可】

Unknown