GDNF and BDNF gene interplay in chronic tinnitus

International Journal of Molecular Epidemiology and Genetics

Sand PG¹  Schecklmann M¹  Langguth B¹  Kleinjung T¹ 

关键词: BDNF;    GDNF;    tinnitus;    sexual dimorphism;    genetic variation;   

DOI  :  

学科分类：流行病学

来源: e-Century Publishing Corporation

【 摘 要 】

Glial cell-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) play key roles in the early development of the central auditory pathway and the inner ear. Both have been successfully employed to treat experimental forms of hearing loss and are likely to operate in a broad spectrum of auditory phenotypes, including phantom perceptions of sound. We conducted a genetic association study addressing five biallelic candidate variants in 240 Caucasian subjects who had been diagnosed with tinnitus for more than 6 months.

【 授权许可】

Unknown