Cell based therapy in Parkinsonism

Translational Neurodegeneration

Erik Ch Wolters¹  Chongsik Lee²  Johannes PJM de Munter³ 

[1] Department of Neurology, UniversitatsSpital, Zurich, Switzerland;Department of Neurology, Asan Medical Center University of Ulsan, Seoel, South Korea;Amarna Stem Cells Group, Maastricht, The Netherlands

关键词: Preclinical;    Expanded MSC;    GDNF;    BDNF;    Multiple system atrophy;    Parkinson’s disease;    Adult stem cells;   

Others  :  838672
DOI  :  10.1186/2047-9158-2-13

 received in 2013-01-29, accepted in 2013-06-02,  发布年份 2013

【 摘 要 】

Parkinson’s disease (PD) is a synucleinopathy-induced chronic progressive neurodegenerative disorder, worldwide affecting about 5 million humans. As of yet, actual therapies are symptomatic, and neuroprotective strategies are an unmet need. Due to their capability to transdifferentiate, to immune modulate and to increase neuroplasticity by producing neurotrophic factors, adult stem cells (ASC) might fill this gap. Preclinical research in 6-hydroxydopamine (6-OHDA) and/or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned animals established persistent improvements of motor behavior after ASC-treatment. Histological/histochemical measurements in these animals evidenced an intracerebral applied ASC-induced increase of Tyrosine Hydroxylase-positive (TH⁺) cells with increased striatal dopamine levels, suggesting cell rescue. Likewise, clinical experience with subventricular applied ASCs in PD patients, although limited, is encouraging, evidencing neurorescue especially during the early phase of the disease. In multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) patients, though, only marginal reduced progression of natural progression could be established after subventricular or intravasal ASC implantations.

【 授权许可】

   
2013 de Munter et al.; licensee BioMed Central Ltd.

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