LRP-1 variation is not associated with risk of Alzheimer's disease

International Journal of Molecular Epidemiology and Genetics

Patrick G Kehoe¹  Seth Love¹  Peter A Passmore¹  Francesco Panza¹  Jonathan A Prince¹  Rachel Barker¹  Katy A Chalmers¹  Davide Seripa¹  Vincenzo Solfrizzi¹ 

关键词: LRP-1;    Alzheimer's disease;    association analysis;   

DOI  :  

学科分类：流行病学

来源: e-Century Publishing Corporation

【 摘 要 】

Alzheimer's disease (AD) is characterised by the extensive deposition of amyloid beta (Aβ) within the parenchyma and vasculature of the brain. It is hypothesised that a dysfunction in Aβ degradation and/or its removal from the brain may result in accumulation as plaques. Low density lipoprotein receptor-related protein-1 (LRP-1) is a multifunctional receptor shown to be involved in cholesterol metabolism but also the removal of Aβ from the brain. Its ability to transport Aβ from the brain to the periphery has made it an attractive candidate for involvement in Alzheimer's disease (AD). We have assessed the frequencies of 9 tag- SNPs and the commonly studied synonymous SNP within exon 3 (rs1799986) in a multi-centre AD/control cohort and performed haplotype analysis. We found no evidence from a combined total of 412 controls and 1057 AD patients to support the involvement of LRP-1 variation, including the most commonly studied variant in rs1799986 in conferring genetic susceptibility to increased risk of AD.

【 授权许可】

Unknown