Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT

American Journal of Nuclear Medicine and Molecular Imaging

Anne-Mette Lebech¹  Andreas Knudsen¹  Eric von Benzon¹  Rasmus S Ripa¹  Sune H Keller¹  Adam E Hansen¹  Annika Loft¹  Anne Mette F Hag¹  Liselotte Højgaard¹  Andreas Kjær¹ 

关键词: Atherosclerosis;    positron emission tomography;    magnetic resonance imaging;    PET/MR;    hybrid scanners;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

The study aimed at comparing PET/MR to PET/CT for imaging the carotid arteries in patients with known increased risk of atherosclerosis. Six HIV-positive men underwent sequential PET/MR and PET/CT of the carotid arteries after injection of 400 MBq of ¹⁸F-FDG. PET/MR was performed a median of 131 min after injection. Subsequently,PET/CT was performed. Regions of interest (ROI) were drawn slice by slice to include the carotid arteries and standardized uptake values (SUV) were calculated from both datasets independently. Quantitative comparison of ¹⁸F-FDG uptake revealed a high congruence between PET data acquired using the PET/MR system compared to the PET/CT system. The mean difference for SUV_mean was -0.18 (p < 0.001) and -0.14 for SUV_max (p < 0.001) indicating a small but significant bias towards lower values using the PET/MR system. The 95% limits of agreement were -0.55 to 0.20 for SUV_mean and -0.93 to 0.65 for SUV_max. The image quality of the PET/MR allowed for delineation of the carotid vessel wall. The correlations between ¹⁸F-FDG uptake from ROI including both vessel wall and vessel lumen to ROI including only the wall were strong (r = 0.98 for SUV_mean and r = 1.00 for SUV_max) indicating that the luminal ¹⁸F-FDG content had minimal influence on the values. The study shows for the first time that simultaneous PET/MR of the carotid arteries is feasible in patients with increased risk of atherosclerosis. Quantification of ¹⁸F-FDG uptake correlated well between PET/MR and PET/CT despite difference in method of PET attenuation correction, reconstruction algorithm, and detector technology.

【 授权许可】

Unknown