Directed differentiation of progenitor cells towards an islet-cell phenotype

American Journal of Stem Cells

Peter R Flatt¹  Charlotte Critchlow¹  Neville H McClenaghan¹  Arif Abed¹  Catriona Kelly¹ 

关键词: Endocrine;    progenitor cells;    islet cells;    insulin production;    diabetes mellitus;   

DOI  :  

学科分类：分子生物学，细胞生物学和基因

来源: e-Century Publishing Corporation

【 摘 要 】

Exogenous insulin administration and oral anti-diabetic drugs are the primary means of treating diabetes. However, tight glycaemic control, with its inherent risk of hypoglycaemia, is required to prevent the microvascular and macrovascular complications of the disease. While islet or pancreas transplantations offer a longer-term cure, their widespread application is not possible, primarily because of a lack of donor tissue, the burden of life-long immunosuppression, and eventual graft rejection. The rapid increase in the incidence of diabetes has promoted the search for alternative cell-based therapies. Here we review recent advances in the directed differentiation of both endocrine and non-endocrine progenitors towards an islet-like phenotype.

【 授权许可】

Unknown