Reversibility of pancreatic β-cells dysfunction after vitamin D and calcium supplementation: a pilot study in a population of obese and prepubescent North-African children

Libyan Journal of Medicine

Ilhem Kacem¹  Jihene Maatoug²  Helmi Ben Saad³  Imed Latiri³  Meriem Gaddas³  Mohamed Salaani⁴  Raoudha Kebaili⁴  Lamia Boughammoura⁴  Nesrine Jaballah⁴ 

[1] Basic Health Center «Sousse Jawhara”, Outpatient consultation, Sousse, Tunisia;Epidemiology Department, Farhat HACHED Hospital of Sousse, University of Sousse, Sousse, Tunisia;Faculté de Médecine de Sousse, Service de Physiologie et Explorations Fonctionnelles, Université de Sousse, Sousse, Tunisie;Paediatrics Department, Farhat HACHED Hospital of Sousse, University of Sousse, Sousse, Tunisia;

关键词: Diabetes-mellitus;    insulin production;    obesity;    Paediatrics;    Tunisia;   

DOI  :  10.1080/19932820.2022.2059896

来源: DOAJ

【 摘 要 】

The mechanisms of diabetogenesis in children remain largely obscure. This study aimed to determine the impact of vitamin D and calcium supplementation on pancreatic β-cells function in terms of insulin secretion and sensitivity. This was a quasi-experimental study involving 30 obese and prepubescent Tunisian children (57% boys). During three months, the children received calcium and vitamin D supplementation at therapeutic doses. An oral glucose tolerance test (OGTT) was performed at the beginning and at the end of the study. The following metabolic definitions were applied: i) hyperinsulinism: insulinemia sum > 300 μ UI/ml during OGTT, ii) insulin-resistance: homeostatic model assessment of insulin-resistance > 2, iii) normal glycaemic profile: normal plasma levels during OGTT without any spike, and iv) pancreatic β-cells dysfunction reversibility: disappearance of the aforementioned disorders. The means ± standard-deviation of age and body mass index were 10.87 ± 1.9 years, and 30.17 ± 4.99 kg/m2, respectively. All children were at the stage of hyperinsulinism associated with insulin-resistance. These disturbances were noted even in children having a normal glycaemic profile at OGTT. After calcium and vitamin D supplementation, glycaemic profile as well as insulin-secretion improved significantly (p < 0.0001). Hyperinsulinism and insulin-resistance decreased significantly by 56.67% (p < 0.0001) and 70.00% (p < 0.0001), respectively. Complete reversibility of these two disorders was noted in 26.6% of children. To conclude, in obese and prepubescent children, vitamin D and calcium supplementation led to the reversibility of the pancreatic β-cells dysfunction.

【 授权许可】

Unknown