Role of toll-like receptors in multiple sclerosis

American journal of clinical and experimental immunology

Alan G Baxter¹  Socorro Miranda-Hernandez¹ 

关键词: Multiple sclerosis;    toll-like receptors;    hygiene hypothesis;    microbial flora;    gene/environment interactions;    autoimmunity;    TLR1;    TLR2;    TLR3;    TLR4;    TLR5;    TLR6;    TLR7;    TLR8;    TLR9;    TLR10;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

Multiple Sclerosis (MS) is an autoimmune disease in which Central Nervous System (CNS) lesions result from perivascular immune cell infiltration associated with damage to myelin, oligodendrocytes and neurons. CNS autoimmunity and its regulation are dominated by the inflammatory cytokines IL17 and IFNγ, and the opposing regulatory cytokines IL10 and the type I IFNs. Toll-like receptors (TLR) play a critical role in modulating cytokine and chemokine secretion in response to exogenous Pathogen Associated to Molecular Patterns and endogenous Danger-Associated to Molecular Patterns. Here, we systematically examine the evidence that TLR play a major role in the initiation disease, the triggering of relapses, and regulation of CNS damage. Data from human studies are supported analyses of a variety of animal models, including Experimental Autoimmune Encephalomyelitis in TLR-deficient mice.

【 授权许可】

Unknown