Immunity and inflammation in neurodegenerative diseases

American Journal of Neurodegenerative Disease

Cristoforo Comi¹  Giuseppe Cappellano¹  Thomas Fleetwood¹  Umberto Dianzani¹  Miryam Carecchio¹  Roberto Cantello¹  Luca Magistrelli¹ 

关键词: Multiple sclerosis;    Alzheimer’s disease;    Parkinsons disease;    neuroinflammation;    neuro-immnue interactions;   

DOI  :  

学科分类：精神健康和精神病学

来源: e-Century Publishing Corporation

【 摘 要 】

Immune reactions inside the central nervous system are finely regulated, thanks to the presence of several checkpoints that have the fundamental purpose to preserve this fragile tissue form harmful events. The current knowledge on the role of neuroinflammation and neuro-immune interactions in the fields of multiple sclerosis, Alzheimer’s disease and Parkinson’s disease is reviewed. Moreover, a focus on the potential role of both active and passive immunotherapy is provided. Finally, we propose a common perspective, which implies that, under pathological conditions, inflammation may exert both detrimental and protective functions, depending on local factors and the timing of immune activation and shutting-off systems.

【 授权许可】

Unknown