Screening of Antimicrobial and Anticancer Potentials of Some Plant Extracts from Mugla Provience

Journal of Applied Biological Sciences

Bahar TÜL¹  Fulya ÇELEBݹ  Hatice GÜNE޹  Müjgan OKTAY¹ 

关键词: Plant extracts;    Anti-microbial activity;    Anti-cancer activity;    Cancer cell lines;   

DOI  :  

学科分类：生物科学（综合）

来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente

【 摘 要 】

Manyphytochemicalsfromdifferentplantspecieshavepotencyintreatmentandpreventionofcancer.Currently,substantialresearchhavebeingcarriedoutinmanylaboratoriestheworldovertodiscovernewplantextractswithhighanticancerand/orantimicrobialactivities.Inthisstudy,sevendifferentplantspeciesGlauciumflavum,Euphorbiafalcata,Conyzacanadensis,Chenopodiumbotrys,Catalpasp.,Quercuscoccifera,CrataegusmonogynafromMuglaregionwereexaminedfortheirantimicrobialandanticancercapacities.DiscdiffusionmethodwasusedtostudyantimicrobialpotencyofethanolextractsagainstGram-positiveandGram-negativebacteria.AnticanceractivitiesoftheplantextractsweretestedagainstthesixdifferentcancercelllinesusingtheMTTassay.ThefruitextractofQ.cocciferawasfoundtobethemosteffectiveextract(13-15mm80μg/discinhibitionzone)againstS.albus,M.luteusandS.aureus.Inaddition,C.canadensisexhibitedantimicrobialactivityonlyagainstE.coliandB.subtilis(10-14mm80μg/mlinhibitionzone).BasedonMTTassays,alloftheplantextractsresultedindifferentdegreesofanticanceractivityonsixdifferentcancercelllines.ThemosteffectiveextractswerefromC.botrys,G.flavum,CatalpaspandQ.cocciferawhichcausedmorethanthreefolddecreaseinthecellproliferationofK562,PC-3andMCF-7celllinescomparedtocontrol.Inconclusion,amongtheseventestedplantextracts,onlyQ.cocciferaandC.canadensisshowedanti-microbialcapacity.Ontheotherhand,4plantextractshavedisplayedhighanticancerpotency.Futurestudiesrelatedwithcelldeathwillelicitthemechanismsofanti-tumoractivitiesoftheplantextracts.

【 授权许可】

Unknown