Fabrication of nanoparticles using Annona squamosa leaf and assessment of its effect on liver (Hep G2) cancer cell line

2nd International Conference on Mining, Material and Metallurgical Engineering

矿业工程;材料科学;冶金学

Vanitha, V.^1 ; Hemalatha, S.^1 ; Pushpabharathi, N.^1 ; Amudha, P.^1 ; Jayalakshmi, M.^1

Department of Biochemistry, Vels University, Velan Nagar, P.V. Vaithiyalingam Road, Pallavaram, Chennai, Tamil Nadu

600 117, India^1

关键词: Annona squamosa;    Bioactive compounds;    Cancer cell lines;    Cancer therapy;    Carcinoma cell lines;    Eco-friendly;    Fourier transform infra red (FTIR) spectroscopy;    Iron oxide nanoparticle;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/191/1/012010/pdf
DOI  :  10.1088/1757-899X/191/1/012010

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Annona squamosa is a fruit bearing plant possesses potent bioactive compounds in all its part. In this present investigation iron oxide nanoparticle was synthesized from hydroethanol extract of Annona squamosa leaves at 60°C temperature. Production of iron oxide nanoparticles in extraction is detected by UV-V spectrophotometer, Scanning electron microscopy was employed to analyse the structure of nanoparticles. Fourier transform infrared spectroscopy (FT-IR) analysis were performed, in order to determine the functional groups on Annona squamosa leaves extract. The synthesized Fe3O4NPs shows potential cytotoxicity against liver carcinoma cell line (HepG2), and there is no toxicity on the normal liver cell line. Our reports confirmed that the Annona squamosa leaf is a very good eco-friendly and nontoxic bioreductant for the synthesis of Iron oxide nanoparticle and opens up further opportunities for fabrication of drugs towards cancer therapy.