Silver metal nanoparticles study for biomedical and green house applications

4th International Conference on Competitive Materials and Technology Processes

Rauwel, E.^1 ; Simón-Gracia, L.^2 ; Guha, M.^3 ; Rauwel, P.^1 ; Kuunal, S.^1 ; Wragg, D.^4

Tartu College, Tallinn Univ. of Technol., Tartu

51008, Estonia^1

Laboratory of Cancer Biology, Institute of Biomedicine, Centre of Excellence for Translational Medicine, University of Tartu, Ravila 14b, Tartu

50411, Estonia^2

Fac. of Medicine, Dept. of Gen. and Mol. Pathology, Univ. of Tartu, Tartu, Estonia^3

Univ. of Oslo, Dpt. of Chemistry and SMN, Oslo

0316, Norway^4

关键词: Biomedical applications;    Cancer cell lines;    Metallic nanoparticles;    Mortality rate;    pH sensitive;    Polymersomes;    Therapeutic treatments;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/175/1/012011/pdf
DOI  :  10.1088/1757-899X/175/1/012011

来源: IOP

【 摘 要 】

Metallic nanoparticles (MNP) with diameters ranging from 2 to 100nm have received extensive attention during the past decades due to their many potential applications. This paper presents a structural and cytotoxicity study of silver metal nanoparticles targeted towards biomedical applications. Spherical Ag MNPs of diameter from 20 to 50 nm have been synthesized. The encapsulation of Ag MNPs inside pH-sensitive polymersomes has been also studied for the development of biomedical applications. A cytotoxicity study of the Ag MNPs against primary prostatic cancer cell line (PPC-1) has demonstrated a high mortality rate for concentrations ranging from 100 to 200mg/L. The paper will discuss the potential for therapeutic treatments of these Ag MNPs.