On the effect of the injection of potassium phosphate in vivo inducing the precipitation of serum calcium with inorganic phosphate

International Journal of Physiology, Pathophysiology and Pharmacology

Letícia B M Soares¹  George Amaro¹  Alcimar B Soares¹  José G Ticianeli¹ 

[1] Laboratory of Biomedical Engineering, Federal University of Uberlândia, Uberlândia, MG, Brazil; Nephrology Service, General Hospital, Federal University of Uberlândia, Uberlândia, MG, Brazil; Brazilian Agricultural Research Company, Boa Vista, RR, Brazil

关键词: In vivo;    potassium phosphate;    inorganic phosphate;    serum calcium;    muscle fatigue;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Highconcentrationsofinorganicphosphate(Pi)resultedfromthehydrolysisofATPisstronglyassociatedtotheweaknessofthecontractilemechanismofmusclesduetoitsattractivenesstocalcium.Themajorityoftheexperimentstostudysucheffectareconductedinvitro.ThisworkinvestigatestheeffectsofdifferentconcentrationsofPi,inducedbytheinjectionofpotassiumphosphateinliveanimals,intheprecipitationwithserumcalciumandthegenerationofcalciumphosphatecomposites.Theexperimentswerealsodesignedtofindouttheidealamountofpotassiumphosphatetoinduceaneffectivereaction.PotassiumphosphatewasinjectedinWistarrats,randomlyseparatedanddistributedintosevengroups.GroupIwasinjectedwith0.5mlofsalinesolution(control)andgroupsIIthroughVIIwereinjectedwith0.5,1.5,2.5,5.0,7.5and10.0mg/kgofpotassiumphosphate,respectively.Bloodcollectedfromtheinferiorvenacavawassubmittedtobiochemicalanalysestomeasuretheconcentrationsofcalcium,Pi,ureaandcreatinine.TheresultsshowedthatPi,inducedbytheinjectionofpotassiumphosphateinliveanimals,causesprecipitationwithserumcalcium,withstatisticallysignificantdifferencesbetweenthecontrolandthetreatmentgroupsfordosesupto5.0mg/kg.Nostatisticallysignificantdifferenceswerefoundbetweenthedifferentdosesandtheconcentrationofureaandcreatinineintheplasma.Weconcludethatpotassiumphosphatecanbeusedtoinduceserumcalciumprecipitationin-vivo,withminoreffectsonotherphysiologicalvariables,andtheidealdosetodosois5.0mg/kg.(IJPPP1310003).

【 授权许可】

Unknown