Synthesis of Substituted Stilbenes via the Knoevenagel Condensation

Molecules

关键词: Knoevenagel condensation;    E-stilbenes;    coumarins;    potassium phosphate;   

DOI  :  10.3390/90800658

来源: mdpi

【 摘 要 】

Knoevenagel condensations between aldehydes and substrates containing active methylene groups were carried out in ethanol at room temperature, in the presence of potassium phosphate, to afford unsymmetrical olefins. These condensations have been shown to afford only the E-isomers in greater than 80% yields. Salicylaldehyde first produces the Knoevenagel condensation products, which undergo a subsequent heterocyclization to give coumarin derivatives. The structures of the synthesized compounds were established on the basis of UV, IR, MS and NMR spectroscopy.

【 授权许可】

Unknown   
© 2004 by MDPI (http:www.mdpi.org).