Effects of a single low-dose acetaminophen on body temperature and running performance in the heat: a pilot project

International Journal of Physiology, Pathophysiology and Pharmacology

Stefanie Kernbeiss¹  Martin Burtscher¹  Marc Philippe¹  Philipp Kofler¹  Hannes Gatterer¹  Veronica Frontull¹  Philipp Krüsmann¹ 

[1] Department of Sport Science, Medical Section, University of Innsbruck, Innsbruck, Austria; Austrian Society for Mountain and High-Altitude Medicine, Innsbruck, Austria; Centre of Technology of Ski and Alpine Sports, Innsbruck, Austria

关键词: Acetaminophen;    heat;    running;    performance;    thermoregulation;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Purpose:Toexaminetheeffectsofasinglelow-dose(500mg)acetaminophenonbodytemperatureandrunningperformanceintheheat(30#176;C).Methods:Thisisarandomized,cross-overpilotstudyperformedinaclimaticchamberattheDepartmentofSportScienceoftheUniversityofInnsbruck.Sevenmalesportstudents(age,25.9#177;2.3years;V#775;O2max,67.3#177;7.1mL/min/kg)participatedinthestudy.Eachparticipantperformedtwoprolongedexercisetestsataconstantintensityonatreadmillatatemperatureof30#176;Catanindividualintensitycorrespondingto70%VO2max.Twohoursbeforeexercisingparticipantswererandomlyassignedtoreceiveacetaminophen(500mg)orplaceboandperformedthesametest2weekslaterwithreversepre-treatment.Results:After20minofrunningintheheatcoretemperatureincreasewaslessunderacetaminophen(P=0.004)andheartrateswerehigher(P=0.02)comparedtoplacebo.Attheendofexerciseneitherrunningtimenorbodytemperaturenorratingsofperceivedexertiondifferedbetweengroups.Conclusion:Althoughtheincreaseincoretemperaturewasslightlyreducedbyacetaminophenafter20minutesofrunningintheheatrunningperformanceremainedunaffectedafterpre-treatmentwithasinglelow-doseofacetaminophen.(IJPPP1307003).

【 授权许可】

Unknown