Functional insights into the core-TFIIH from a comparative survey

Genomics

Odile Lecompte¹  Olivier Poch¹  Raymond Ripp¹  Xavier Brochet¹  Florence Bedez¹  Julie D. Thompson¹  Dino Moras¹  Benjamin Linard¹ 

[1] Laboratoire de Bioinformatique et Génomique Intégratives, Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS, INSERM, UDS), BP163, 67404 Illkirch Cedex, France

关键词: TFIIH;    Transcription;    Repair;    Splicing;    Comparative genomic analysis;    P34;   

DOI  :  10.1016/j.ygeno.2012.11.003

学科分类：医学（综合）

来源: Academic Press

【 摘 要 】

TFIIHisaeukaryoticcomplexcomposedoftwosubcomplexes,theCAK(Cdkactivatingkinase)andthecore-TFIIH.Thecore-TFIIH,composedofsevensubunits(XPB,XPD,P62,P52,P44,P34,andP8),playsacrucialroleintranscriptionandrepair.Here,weperformedanextendedsequenceanalysistoestablishtheaccuratephylogeneticdistributionofthecore-TFIIHin63eukaryoticorganisms.Inspiteofthehighconservationofthesevensubunitsatthesequenceandgenomiclevels,thenon-enzymaticP8,P34,P52andP62areabsentfromoneorafewunicellularspecies.Togaininsightintotheirrespectiveroles,weundertookacomparativegenomicanalysisofthewholeproteometoidentifythegenesetssharingsimilarpresence/absencepatterns.WhilelittleinformationwasinferredforP8andP62,ourstudiesconfirmtheknownroleofP52inrepairandsuggestforthefirsttimetheimplicationofthecoreTFIIHinmRNAsplicingviaP34.

【 授权许可】

Unknown   

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