Developmental Biology | |
Neurogenin1 Defines Zebrafish Cranial Sensory Ganglia Precursors | |
David W. Raible1  Peter Andermann1  Josette Ungos1  | |
[1] Department of Biological Structure, University of Washington, Seattle, Washington, 98195-7420 | |
关键词: trigeminal placode; lateral line; epibranchial placode; otic placode; neurogenin; bHLH transcription factor; morpholino oligonucleotides; | |
DOI : 10.1006/dbio.2002.0820 | |
学科分类:生物科学(综合) | |
来源: Academic Press | |
【 摘 要 】
Cellsdelaminatefromepithelialplacodestoformsensorygangliainthevertebratehead.Wedescribetheformationofcranialneurogenicplacodesinthezebrafish,Daniorerio,usingbHLHtranscriptionfactorsasmolecularmarkers.Asingleneurogeningene,neurogenin1(ngn1),isrequiredforthedevelopmentofallzebrafishcranialganglia,whichcontrastswithotherdescribedvertebrates.Expressionofngn1delineateszebrafishganglionicplacodes,includingtrigeminal,lateralline,andepibranchialplacodes.Inaddition,ngn1isexpressedinasubsetofcellswithintheoticvesiclethatwilldelaminatetoformtheoctaval(statoacoustic)ganglion.Thetrigeminalplacodeisthefirsttodifferentiate,andformsjustlateralandadjacenttotheneuralcrest.Expressionofngn1istransientandprefiguresexpressionofarelatedbHLHtranscriptionfactor,neuroD.Interferingwithngn1functionusingaspecificantisensemorpholinooligonucleotideblocksdifferentiationofallcranialgangliabutnotassociatedglialcells.Laterallinesensoryneuromastsdevelopindependentlyofngn1function,suggestingthattwoderivativesoflaterallineplacodes,gangliaandmigratingprimordia,areunderseparategeneticcontrol.
【 授权许可】
Unknown
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