Anteroposterior Patterning in Adult Abdominal Segments of Drosophila

Developmental Biology

Artyom Kopp¹  Ian Duncan¹ 

[1] Department of Biology, Washington University, St. Louis, Missouri, 63130

关键词: hedgehog;    engrailed;    optomotor-blind;    segment polarity;    homeotic genes;    bithorax complex;    abdominal histoblasts;   

DOI  :  10.1006/dbio.2001.0529

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

ThecuticleoftheadultabdomenofDrosophilaisproducedbynestsofimaginalhistoblasts,whichproliferateandmigrateduringmetamorphosistoreplacethepolyploidlarvalepidermalcells.Inthisreport,wepresentadetaileddescriptionoftheexpressionoffourkeypatterninggenes,engrailed(en),hedgehog(hh),patched(ptc),andoptomotor-blind(omb),inabdominalhistoblastsduringthefirst42hafterpupariation,aperiodinwhichtheadultpatternisestablished.Inaddition,wedescribetheexpressionofthehomeoticgenesUltrabithorax,abdominal-A,andAbdominal-B,whichspecifythefatesofadultabdominalsegments.Ourresultsindicatethatabdominalsegmentsdevelopinisolationfromoneanotherduringearlypupalstages,andthatsomepatterningeventsareindependentofhh,wingless,anddecapentaplegicsignaling.WeshowthatpatternandpolarityinalargeanteriorportionofthesegmentarespecifiedwithoutinputfromHh,andpresentevidencethatabdominaltergitespossessanunderlyingsymmetricpatternuponwhichpatterningbyHhissuperimposed.Thesignalsresponsibleforthisunderlyingsymmetryremaintobeidentified.

【 授权许可】

Unknown