Negative regulation of Ultrabithorax expression by engrailed is required for proper specification of wing development in Drosophila melanogaster

Journal of genetics

L. S. Shashidhara1¹  B. Starling Emerald¹ 

[1] the function of the segment polarity gene engrailed (en) is critical to keep the homeotic selector gene Ultrabithorax (Ubx) repressed in wing imaginal discs,$$

关键词: homeosis;    Drosophila;    wing;    haltere;    Ultrabithorax;    engrailed;    hedgehog.;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

In both vertebrates and invertebrates, homeotic selector genes confer morphological differences along the antero-posterior axis. However, insect wing development is independent of all homeotic gene functions, reflecting the ground plan of an ancestral pterygote, which bore wings on all segments. Dipteran insects such as Drosophila are characterized by a pair of wings in the mesothoracic segment. In all other segments, wing development is essentially repressed by different homeotic genes, although in the metathorax they are modified into a pair of halteres. This necessitates that during development all homeotic genes are to be maintained in a repressed state in wing imaginal discs. In this report we show thatthe function of the segment polarity gene engrailed (en) is critical to keep the homeotic selector gene Ultrabithorax (Ubx) repressed in wing imaginal discs,

【 授权许可】

Unknown