Effects of Nipradilol, a Nitric Oxide-Releasing β-Adrenoceptor Blocking Agent, on Phosphoenolpyruvate Carboxykinase Gene Transcription in a Rat Hepatoma Cell Line

The Japanese Journal of Pharmacology

Yoshihiro Nishimura¹  Toru Aizawa¹  Mitsuhisa Komatsu¹  Sachiko Ikeo¹  Koji Nakajima¹  Keishi Yamauchi¹  Kiyoshi Hashizume¹ 

[1] Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine

关键词: Dexamethasone;    Phosphoenolpyruvate carboxykinase;    Nipradilol;   

DOI  :  10.1254/jjp.87.83

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(13)Cited-By(3)Effects of nipradilol, a β-adrenoceptor blocker with a nitroxy moiety, on phosphoenolpyruvate carboxykinase (PEPCK) gene transcription were examined using a rat hepatoma cell line, H4IIE cells. Dexamethasone was employed as an enhancer of PEPCK gene transcription. Nipradilol, but not timolol (a β-blocker without a nitroxy moiety), attenuated PEPCK gene transcription both in the control and the dexamethasone-treated cells. The effects of nipradilol were eradicated by methylene blue (an inhibitor of cellular guanylate cyclase). Nipradilol is a unique β-blocker that suppresses PEPCK gene transcription in hepatocytes likely through liberation of nitric oxide and resultant activation of guanylate cyclase.

【 授权许可】

Unknown