The Effect of Nipradilol on the Isoproterenol-Induced Depression of Contractions in the Cat Soleus Muscle

The Japanese Journal of Pharmacology

Nozomu Murata²  Yoichi Yamauchi¹  Toshihiko Tanaka² 

[1] Tokyo Research Laboratories, Pharmaceutical Division, Kowa Company, Ltd.;Gifu Research Laboratory, JBC Inc.

关键词: Nipradilol;    β-Blocker;    Cat soleus muscle;    β2-Adrenoceptor;    Isoproterenol;   

DOI  :  10.1254/jjp.81.286

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(17)The effect of nipradilol on the isoproterelol-induced depression of contractions of the soleus muscle of the anesthetized cats was studied. Isoproterenol (0.3 μg/kg) injected intravenously decreased the tension and degree of fusion of incomplete tetanic contractions of the soleus muscle of the anesthetized cats. The effect of isoproterenol was blocked by nipradilol (≥3 μg/kg), desnitro-nipradilol (≥10 μg/kg) and propranolol (≥10 μg/kg), but not by nitroglycerin (10 - 100 μg/kg). Nipradilol (30 μg/kg) and desnitro-nipradilol (300 μg/kg) almost completely antagonized the depressor effects of isoproterenol. These results coupled with evidence that nipradilol does not penetrate the blood-brain barrier indicate that nipradilol exerts an anti-tremor action by blocking peripheral β2-adrenoceptors.

【 授权许可】

Unknown