The Japanese Journal of Pharmacology | |
Regulation of Endothelial Nitric Oxide Synthase and Endothelin-1 Expression by Fluvastatin in Human Vascular Endothelial Cells | |
Taku Matsubara1  Matomo Nishio3  Tadashi Yamamoto2  Kazuyuki Ozaki1  Yoshifusa Aizawa1  Takaharu Ishibashi3  | |
[1] First Department of Internal Medicine;Department of Renal Pathology, Institute of Nephrology, Niigata University School of Medicine;Department of Pharmacology, Kanazawa Medical University | |
关键词: Fluvastatin; 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor; Nitric oxide; Endothelin-1; Endothelial cell; | |
DOI : 10.1254/jjp.85.147 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(36)Cited-By(10)We investigated the effects of fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on endothelial vasoactive substances using human umbilical vein endothelial cells (HUVECs). Incubation of HUVECs with fluvastatin for 12 h increased endothelial nitric oxide synthase (eNOS) mRNA expression in a concentration-dependent manner (peak, 276 ± 38%, mean ± S.D., of the control, at 1.0 μM fluvastatin, P &0.01). In addition, fluvastatin increased eNOS protein production (245 ± 51% of the control level, P<0.05) as well as nitrite production (165 ± 35% of the control level, P<0.01). In contrast, incubation of HUVECs with 1.0 μM fluvastatin for 12 h significantly reduced the production of endothelin-1 (ET-1) and preproET-1 mRNA expression in HUVECs (28 ± 1% and 39 ± 1% of the control level, respectively, P <0.01). Our results suggest that fluvastatin might be involved in improvement of endothelial function and prevention of the progression of atherosclerosis.
【 授权许可】
Unknown
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