Preferable Effect of Pravastatin Compared to Atorvastatin on Beta Cell Function in Japanese Early-state Type 2 Diabetes with Hypercholesterolemia

Endocrine Journal

Takeshi OGIHARA¹  Ryuzo KAWAMORI¹  Tomoya MITA¹  Hiroshi UCHINO¹  Hirotaka WATADA¹  Tomoaki SHIMIZU¹  Michiko ABE¹  Shiho NAKAYAMA¹  Takahisa HIROSE¹ 

[1] Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine

关键词: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor;    Type 2 diabetes mellitus;    Pancreatic beta cell;    Hyperlipidemia;    Clinical trial;   

DOI  :  10.1507/endocrj.K06-198

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(35)Cited-By(20)While a large numbers of clinical trials using various kinds of statins has been reported, a possible preventive effect on new onset of type 2 diabetes mellitus was shown only by the subanalysis of The West of Scotland Coronary Prevention Study (WOSCOPS) using pravastatin. The aim of this study was to investigate whether pravastatin has a preferable effect on glucose tolerance among statins. An open-label prospective cross-over trial was performed to compare the effect of pravastatin (10 mg/day) or atorvastatin (10 mg/day) in Japanese early-state type 2 diabetes mellitus with hypercholesterolemia. The analyzed study subjects were treated with pravastatin (10 mg/day, n = 12) or atorvastatin (10 mg/day, n = 12) for 12 weeks. After a 4-week-washout period, the drugs were switched and treatment was continued for another 12 weeks. Oral glucose tolerance test (OGTT) was performed to evaluate several parameters including the appropriateness of beta cell function for the individual insulin sensitivity (disposition index: product of a validated secretion parameter and sensitivity) at the end of each therapy. HbA1c and 2 h-glucose levels during OGTT in the pravastatin treatment were significantly lower than atorvastatin treatment. Disposition index after pravastatin treatment was significantly higher than after atorvastatin treatment. In conclusion, our study suggests that pravastatin has a favorable effect on pancreatic beta cell function compared with atorvastatin.

【 授权许可】

Unknown