FEBS Letters | |
Differential effects of endogenous and exogenous nitric oxide on the release of endothelin‐1 from the intact perfused rat adrenal gland in situ | |
Hinson, J.P.1  Cameron, L.A.1  Kapas, S.1  | |
[1] Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, Mile End Road, London E1 4NS, UK | |
关键词: Endothelin-1; Nitric oxide; Adrenal; | |
DOI : 10.1016/0014-5793(95)01467-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Studies using an inhibitor of nitric oxide (NO) synthesis have suggested that endogenous NO may have a role in regulating endothelin release. We investigated the effect of endogenous and exogenous nitric oxide (NO) on the release of irET-1. l-NAME stimulated, but l-arginine inhibited irET-1 release. Perfusing sodium nitroprusside (SNP), however, did not inhibit irET-1 secretion. CyclicGMP, the second messenger for NO action, was stimulated by SNP but not by l-arginine. These data demonstrate that endogenous NO inhibits of irET-1, in a manner which is independent of cGMP, and suggest that this action may contribute to the vasodilatory effect of NO.
【 授权许可】
Unknown
【 预 览 】
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