Differential effects of endogenous and exogenous nitric oxide on the release of endothelin‐1 from the intact perfused rat adrenal gland in situ

FEBS Letters

Hinson, J.P.¹  Cameron, L.A.¹  Kapas, S.¹ 

[1] Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, Mile End Road, London E1 4NS, UK

关键词: Endothelin-1;    Nitric oxide;    Adrenal;   

DOI  :  10.1016/0014-5793(95)01467-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Studies using an inhibitor of nitric oxide (NO) synthesis have suggested that endogenous NO may have a role in regulating endothelin release. We investigated the effect of endogenous and exogenous nitric oxide (NO) on the release of irET-1. l-NAME stimulated, but l-arginine inhibited irET-1 release. Perfusing sodium nitroprusside (SNP), however, did not inhibit irET-1 secretion. CyclicGMP, the second messenger for NO action, was stimulated by SNP but not by l-arginine. These data demonstrate that endogenous NO inhibits of irET-1, in a manner which is independent of cGMP, and suggest that this action may contribute to the vasodilatory effect of NO.

【 授权许可】

Unknown