Food Deprivation Depletes Gastric Mucus Glycoprotein in Streptozotocin-Induced Diabetic Rats

The Japanese Journal of Pharmacology

Mine Kinoshita¹  Hiroshi Narita¹  Eisuke Kume¹  Shigeki Igarashi¹ 

[1] Discovery Research Laboratory,Tanabe Seiyaku Co.,Ltd.,2-2-50 Kawagishi,Toda-shi,Saitama 335-8505,Japan

关键词: Fasting;    Gastric lesion;    Gastric mucus glycoprotein;    Streptozotocin-induced diabetic rats;   

DOI  :  10.1254/jjp.84.51

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(19)Cited-By(3)Fasting causes gastric mucosal damage in streptozotocin(STZ)−induced diabetic rats, but its pathogenic mechanism remains to be elucidated.The aim of the present study was to investigate the alteration of gastric mucosal mucin, one of the gastric defensive factors against the developmet of such damage.Diabetes was induced in rats by intravenous injection of STZ(65 mg/kg).The experiments were performed using 4−week STZ−diabetic rats with blood glucose levels above 350 mg/dl.The amount of gastric mucus glycoprotein was determined by gel filtration, and the distribution of neutral and acidic mucins in the stomach epithelium was examined by histochemical analysis.In normal rats, 24−h fasting neither affected the gastric mucin content nor caused any macroscopic gastric mucosal injury.In contrast, starvation significantly reduced the amount of total gastric mucus glycoprotein prior to the formation of mucosal lesions in the STZ−diabetic rats.Nine hours after food deprivation, the gastric damage developed in about 70% of the diabetic rats, the amount of mucus glycoprotein markedly decreased, and both the neutral and acidic mucins diminished in the epithelium.Taken together, in STZ−diabetic rats, fasting by itself depletes gastric mucus glycoprotein, and this depletion may be involved in the pathogenic mechanism of the formation of gastric mucosal lesions.

【 授权许可】

Unknown