Preventive Actions of N-(3-Aminopropionyl)-L-Histidinato Zinc (Z-103) through Increases in the Activities of Oxygen-Derived Free Radical Scavenging Enzymes in the Gastric Mucosa on Ethanol-Induced Gastric Mucosal Damage in Rats

The Japanese Journal of Pharmacology

Daisuke Shii¹  Yoshio Suzuki¹  Ryoji Kojima¹  Tetsuya Segami¹  Mikio Ito¹ 

[1] Department of Pharmacology, Faculty of Pharmacy, Meijo University

关键词: Z-103;    Ethanol;    Gastric lesion;    Superoxide dismutase;    Glutathione peroxidase;   

DOI  :  10.1254/jjp.59.267

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(25)Cited-By(19)Z-103 at 1 to 25 mg/kg, p.o. prevented 100% ethanol-induced gastric mucosal lesions in a dose-dependent manner. Z-103 at 3 to 25 mg/kg, p.o. significantly elevated gastric mucosal super-oxide dismutase (SOD)-like activity 1 hr after its administration to normal rats. In addition, Z-103 at doses (10 and 25 mg/kg, p.o.) which prevented 100% ethanol-induced gastric lesion further increased gastric mucosal SOD-like and glutathione peroxidase (GSH-px) activities elevated by 60% ethanol. Z-103 (10 and 25 mg/kg) significantly inhibited the increase in thiobarbituric acid-reactive substances in gastric mucosa injured by 60% ethanol. The combination with cycloheximide, a protein synthesis inhibitor, completely abolished the prevention of 60% ethanol-induced gastric mucosal lesions and the elevation of both free radical scavenging enzyme activities in the mucosa by Z-103 (10 mg/kg, p.o.). These results suggest that Z-103 may partly protect rat gastric mucosa against ethanol-induced damage by scavenging oxygen-derived free radicals via increases in the synthesis of SOD-like and GSH-px enzymes in the mucosa.

【 授权许可】

Unknown