Protective Effects of Arbaprostil against Indomethacin-Induced Gastric Lesions in Rats: Significance of Maintained Gastric Blood Flow

The Japanese Journal of Pharmacology

Hisanori Takanashi¹  Michitaka Akima¹ 

[1] Department of Pharmacology, Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.

关键词: Arbaprostil;    Gastric blood flow;    Indomethacin;    Gastric lesion;    Nonradioactive microsphere;   

DOI  :  10.1254/jjp.59.349

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(29)Cited-By(3)The purpose of the present study was to investigate the relationship between the effects of 15(R)-15-methylprostaglandin E2 (arbaprostil) on gastric blood flow (GBF) and its protective effects on gastric lesions in rats. The GBF of anesthetized rats was measured by two different methods: Total blood flow into the stomach (total GBF) was determined by means of an ultrasonic pulsed Doppler flow meter; and gastric mucosal blood flow (mucosal GBF) was measured by nonradioactive microspheres. Systemic blood pressure (SBP), heart rate (HR) and gastric vascular resistance (GVR) were recorded simultaneously. Arbaprostil (10-100 μg/kg) given i.v. did not affect resting total or mucosal GBF even though it decreased SBP and GVR. Significant improvement of the total and mucosal GBF decreased by indomethacin pretreatment (10 mg/kg, i.v.) was observed by administration of arbaprostil (10-100 μg/kg, i.v.) in a dose-dependent manner. Furthermore, i.v.-administration of this agent, in the same dose-range, prevented the formation of gastric lesions induced by indomethacin. The present result suggests that mitigation for the ischemic state of the gastric mucosa may be one of the important mechanisms for the prophylactic and curative effect of arbaprostil on gastric lesions induced by indomethacin.

【 授权许可】

Unknown