Molecular Basis of Spatio-temporal Dynamics in Inositol 1, 4, 5-Trisphosphate-Mediated Ca2+ Signalling

The Japanese Journal of Pharmacology

Masamitsu Iino¹ 

[1] Department of Pharmacology,Graduate School of Medicine,The University of Tokyo;and CREST,Japan Science and Technology Corporation,Tokyo 113-0033,Japan

关键词: Ca2+ wave;    Ca2+ oscillation;    Inositol 1;    4;    5-trisphosphate receptor;    Phospholipase C;   

DOI  :  10.1254/jjp.82.15

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(41)Cited-By(11)Inositol 1, 4, 5−trisphosphate(IP3)−mediated Ca2+ signalling regulates many important cell functions, and the spatio−temporal dynamics of the Ca2+ signalling is a crucial factor for its versatility.The molecular mechanisms that control Ca2+ signalling are now being investigated, and I here describe the subtypes of IP3 receptors that have distinct functional properties and contribute to the diversity of Ca2+ signalling patterns.I also discuss the spatio−temporal dynamics of intracellular IP3 concentration, describing recent methodological advances in monitoring intracellular IP3 concentration.These findings highlight the potential importance of the spatio−temporal information of any signalling molecule.

【 授权许可】

Unknown