The Japanese Journal of Pharmacology | |
Molecular Basis of Spatio-temporal Dynamics in Inositol 1, 4, 5-Trisphosphate-Mediated Ca2+ Signalling | |
Masamitsu Iino1  | |
[1] Department of Pharmacology,Graduate School of Medicine,The University of Tokyo;and CREST,Japan Science and Technology Corporation,Tokyo 113-0033,Japan | |
关键词: Ca2+ wave; Ca2+ oscillation; Inositol 1; 4; 5-trisphosphate receptor; Phospholipase C; | |
DOI : 10.1254/jjp.82.15 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(41)Cited-By(11)Inositol 1, 4, 5−trisphosphate(IP3)−mediated Ca2+ signalling regulates many important cell functions, and the spatio−temporal dynamics of the Ca2+ signalling is a crucial factor for its versatility.The molecular mechanisms that control Ca2+ signalling are now being investigated, and I here describe the subtypes of IP3 receptors that have distinct functional properties and contribute to the diversity of Ca2+ signalling patterns.I also discuss the spatio−temporal dynamics of intracellular IP3 concentration, describing recent methodological advances in monitoring intracellular IP3 concentration.These findings highlight the potential importance of the spatio−temporal information of any signalling molecule.
【 授权许可】
Unknown
【 预 览 】
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RO201912080714605ZK.pdf | 489KB | download |