The Japanese Journal of Pharmacology | |
Stimulation of In Vitro Angiogenesis by Tetrahydrobiopterin in Bovine Aortic Endothelial Cells | |
Tsutomu Nagai2  Toshinori Yamamoto2  Yuji Kiuchi1  Masako Yasuda2  Masakazu Ishii2  Shunichi Shimizu1  | |
[1] Departments of Pathophysiology, School of Pharmaceutical Sciences, Showa University;Departments of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University | |
关键词: Tetrahydrobiopterin; Angiogenesis; Proliferation; | |
DOI : 10.1254/jjp.80.177 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(15)Cited-By(8)This study examined whether tetrahydrobiopterin (BH4) stimulates angiogenesis by measuring the formation of tube-like structures in vascular endothelial cells. Bovine aortic endothelial cells that were cultured between two layers of collagen type I gel formed tube-like networks. Addition of BH4 or sepiapterin, a precursor of BH4 synthesis, stimulated the formation of tube-like structures. The sepiapterin-stimulated tube formation was completely inhibited by co-treatment with N-acetylserotonin, an inhibitor of sepiapterin reductase. These findings show that BH4 stimulates in vitro angiogenesis in vascular endothelial cells.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912080714514ZK.pdf | 473KB | download |