The Role of Calcium in the Etiology of the Affective Disorders

The Japanese Journal of Pharmacology

Daiga M. Helmeste¹  Siu Wa Tang¹ 

[1] Department of Psychiatry, University of California, Irvine, North Campus Zot 1681

关键词: Intracellular signaling;    Calcium;    Platelet;    Serotonin;    Affective disorder;   

DOI  :  10.1254/jjp.77.107

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(82)Cited-By(7)Calcium abnormalities are some of the more consistent findings in platelets of affective disorder patients. While medication status does not correlate with this finding, antidepressants do modulate intracellular calcium. This, in combination with reports that calcium channel inhibitors may have antidepressant potential, suggests that calcium may play an important role in this disorder. This paper reviews the specificity of calcium abnormalities for the affective disorders and also discusses possible mechanisms of action.

【 授权许可】

Unknown