Inhibition by [Arg8]-Vasopressin of Long Term Potentiation in Guinea Pig Hippocampal Slice

The Japanese Journal of Pharmacology

Shuji Kaneko³  Akinori Akaike²  Masamichi Satoh¹  Takehiko Maeda²  Einosuke Sakurai¹ 

[1] Departments of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University;Departments of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University;Departments of Neuropharmacology, Faculty of Pharmaceutical Sciences, Kyoto University

关键词: [Arg8]-vasopressin;    Long term potentiation;    Hippocampus;   

DOI  :  10.1254/jjp.77.103

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(12)Cited-By(5)We examined the effects of [Arg8]-vasopressin (AVP) on long term potentiation (LTP) of the field excitatory postsynaptic potentials at CA1 and CA3 synapses in adult guinea pig hippocampal slices. AVP (10 nM) depressed the magnitude of LTP without any effects on basal responses at both synaptic pathways. The depressive effect by AVP at CA1 synapses appears to be receptor-mediated since it was inhibited by an AVP V1-receptor antagonist, [Pmp1, Tyr(Me)2]-AVP. From these results, AVP may play an inhibitory role on the induction of LTP via V1 receptors in the guinea pig hippocampus.

【 授权许可】

Unknown