Phorbol ester inhibition of vasopressin‐induced calcium efflux from cultured rat aortic myocytes

FEBS Letters

Stoclet, Jean-Claude¹  Lassegue, Bernard¹ 

[1] Laboratoire de Pharmacodynamie, Université Louis Pasteur, CNRS UA 600, INSERM U243, BP 10, F67048 Strasbourg Cedex, France

关键词: Phorbol ester Protein kinase C Vasopressin45Ca2+ efflux Vascular smooth muscle);    AVP;    [Arg8]-vasopressin;    TPA;    12-O-tetradecanoylphorbol 13-acetate;    PMT-AVP;    [(β-mercapto-β;    β-cyclopentamethylene propionic acid)1;    (O-methyl)Tyr2Arg8]-vasopressin;   

DOI  :  10.1016/0014-5793(86)80907-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of the protein kinase C activator TPA was investigated on AVP-induced ⁴⁵Ca release from rat aortic myocytes. In the nanomolar range TPA, but not 4β-phorbol, reduced the brief ⁴⁵Ca efflux produced by AVP in the presence or in the absence of extracellular calcium. The maximal effect of TPA was to abolish the response to a half maximally active concentration of AVP, and to reduce by 50% the maximal response to the hormone. These results suggest that protein kinase C activation can exert a negative control on the early AVP-induced calcium mobilization in vascular smooth muscle.

【 授权许可】

Unknown