Histological Evidence for Neuroprotective Action of Nebracetam on Ischemic Neuronal Injury in the Hippocampus of Stroke-Prone Spontaneously Hypertensive

The Japanese Journal of Pharmacology

Kimihiro Yamashita²  Yasuko Kohno¹  Mihoko N. Nakashima³  Yasufumi Kataoka²  Masataka Ichikawa³  Masami Kohzuma²  Masami Niwa⁴  Kohtaro Taniyama² 

[1] Department of Pharmacology, Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim;Department of Pharmacology 2, Nagasaki University School of Medicine;Department of Hospital Pharmacy, Nagasaki University School of Medicine;Department of Pharmacology 1, Nagasaki University School of Medicine

关键词: Nebracetam;    Ischemic hippocampal damage;    Stroke-prone spontaneously hypertensive rat;   

DOI  :  10.1254/jjp.67.91

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(4)The protective effect of nebracetam on ischemic neuronal damage was histologically examined in the pyramidal cell layer of the hippocampal CAI subfield 7 days after operation using stroke-prone spontaneously hypertensive rats (SHRSP) subjected to 10-min bilateral carotid occlusion. Nebracetam (50 and 100 mg/kg), given orally 10 min after reperfusion, dose-dependently protected against ischemic delayed neuronal damage in the SHRSP with occlusion; however, the blood pressure remained unchanged following nebracetam administration. These findings further support the notion that nebracetam protects against ischemic delayed neuronal cell death in the hippocampus.

【 授权许可】

Unknown