The Japanese Journal of Pharmacology | |
Neuroprotective Effect of TTC-909, an Isocarbacyclin Methyl Ester Incorporated in Lipid Microspheres, on Hippocampal Delayed Neuronal Death of Stroke-Prone Spontaneously Hypertensive Rats | |
Kimihiro Yamashita4  Yasuko S.-Yamashita4  Mihoko N.-Nakashima1  Yasufumi Kataoka4  Hiroaki Araki3  Hirofumi Tanabe2  Masami Niwa4  Kohtaro Taniyama4  | |
[1] Departments of Hospital Pharmacy, Nagasaki University School of Medicine;Pharmacological Research Department, Pharmaceuticals Development Research Laboratories, Teijin Insutitute for Bio-medical Research, Teijin Ltd.;Pharmacology Laboratory, Pharmaceutical Research Laboratories, Taisho Pharmaceutical Co., Ltd.;Departments of Pharmacology, Nagasaki University School of Medicine | |
关键词: Ischemia-related delayed neuronal death; Prostacyclin analogue; Stroke-prone spontaneously hypertensive rat; | |
DOI : 10.1254/jjp.71.351 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(15)Cited-By(7)TTC-909 is a newly developed isocarbacyclin methyl ester (TEI-9090) incorporated in lipid microspheres. The neuroprotective effect of TTC-909 was histologically examined in the pyramidal cell layer of the hippocampus CA1 subfield 7 days after transient forebrain ischemia using stroke-prone spontaneously hypertensive rats. TTC-909, given intravenously 10 min after the transient forebrain ischemia, dose-dependently protected against ischemia-related delayed neuronal death. The blood pressure remained unchanged following TTC-909 administration. This finding suggests that TTC-909 has a neuroprotective action on ischemic delayed neuronal death in the hippocampus.
【 授权许可】
Unknown
【 预 览 】
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