Neuroprotective Effect of TTC-909, an Isocarbacyclin Methyl Ester Incorporated in Lipid Microspheres, on Hippocampal Delayed Neuronal Death of Stroke-Prone Spontaneously Hypertensive Rats

The Japanese Journal of Pharmacology

Kimihiro Yamashita⁴  Yasuko S.-Yamashita⁴  Mihoko N.-Nakashima¹  Yasufumi Kataoka⁴  Hiroaki Araki³  Hirofumi Tanabe²  Masami Niwa⁴  Kohtaro Taniyama⁴ 

[1] Departments of Hospital Pharmacy, Nagasaki University School of Medicine;Pharmacological Research Department, Pharmaceuticals Development Research Laboratories, Teijin Insutitute for Bio-medical Research, Teijin Ltd.;Pharmacology Laboratory, Pharmaceutical Research Laboratories, Taisho Pharmaceutical Co., Ltd.;Departments of Pharmacology, Nagasaki University School of Medicine

关键词: Ischemia-related delayed neuronal death;    Prostacyclin analogue;    Stroke-prone spontaneously hypertensive rat;   

DOI  :  10.1254/jjp.71.351

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(7)TTC-909 is a newly developed isocarbacyclin methyl ester (TEI-9090) incorporated in lipid microspheres. The neuroprotective effect of TTC-909 was histologically examined in the pyramidal cell layer of the hippocampus CA1 subfield 7 days after transient forebrain ischemia using stroke-prone spontaneously hypertensive rats. TTC-909, given intravenously 10 min after the transient forebrain ischemia, dose-dependently protected against ischemia-related delayed neuronal death. The blood pressure remained unchanged following TTC-909 administration. This finding suggests that TTC-909 has a neuroprotective action on ischemic delayed neuronal death in the hippocampus.

【 授权许可】

Unknown