Nebracetam (WEB 1881FU) Prevents N-Methyl-D-Aspartate Receptor-Mediated Neurotoxicity in Rat Striatal Slices

The Japanese Journal of Pharmacology

Shigenori Watanabe¹  Yasufumi Kataoka²  Masami Kouzuma²  Masami Niwa²  Kohtaro Taniyama²  Shuichi Koizumi¹ 

[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University;Department of Pharmacology 2, Nagasaki University School of Medicine

关键词: Nebracetam;    Neuroprotective action;    Striatal slices (rat);   

DOI  :  10.1254/jjp.59.247

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(13)Cited-By(3)The effects of nebracetam were investigated on N-methyl-D-aspartate (NMDA) receptor- and voltage-operated Ca2+ channels (VOCC)-mediated neural dysfunction by directly monitoring the real-time dynamics of dopamine released from rat striatal slices. Nebracetam (10-5 and 10-4 M) completely protected against striatal dopaminergic impairment induced by L-glutamate and NMDA, respectively. BAY K-8644-evoked striatal dysfunction was not blocked by nebracetam (10-4 M). Therefore, nebracetam seems to produce a neuroprotective action by interacting, at least in part, with NMDA receptor-operated Ca2+ channels.

【 授权许可】

Unknown