The Japanese Journal of Pharmacology | |
Nebracetam (WEB 1881FU) Prevents N-Methyl-D-Aspartate Receptor-Mediated Neurotoxicity in Rat Striatal Slices | |
Shigenori Watanabe1  Yasufumi Kataoka2  Masami Kouzuma2  Masami Niwa2  Kohtaro Taniyama2  Shuichi Koizumi1  | |
[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University;Department of Pharmacology 2, Nagasaki University School of Medicine | |
关键词: Nebracetam; Neuroprotective action; Striatal slices (rat); | |
DOI : 10.1254/jjp.59.247 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(13)Cited-By(3)The effects of nebracetam were investigated on N-methyl-D-aspartate (NMDA) receptor- and voltage-operated Ca2+ channels (VOCC)-mediated neural dysfunction by directly monitoring the real-time dynamics of dopamine released from rat striatal slices. Nebracetam (10-5 and 10-4 M) completely protected against striatal dopaminergic impairment induced by L-glutamate and NMDA, respectively. BAY K-8644-evoked striatal dysfunction was not blocked by nebracetam (10-4 M). Therefore, nebracetam seems to produce a neuroprotective action by interacting, at least in part, with NMDA receptor-operated Ca2+ channels.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912080713334ZK.pdf | 319KB | download |