Antiemetic Effects of Serotonergic 5-HT1A-Receptor Agonists in Suncus Murinus

The Japanese Journal of Pharmacology

Fumihiko Okada¹  Hiroshi Saito¹  Norio Matsuki¹  Yoshifumi Torii¹ 

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Science, The University of Tokyo

关键词: 5-HT1A receptor;    Motion sickness;    Emesis;    Suncus;    Cisplatin;   

DOI  :  10.1254/jjp.64.109

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(19)Cited-By(43)The antiemetic effects of six serotonergic 5-HT1A-receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetrarin (8-OH-DPAT), 4-{4-[4-(2-pyrimidinyl)piperazin-l-yl]butyl}-2, 3, 4, 5-tetrahydro-l, 4-benzo-xazepine-3, 5-dione (SUN8399), buspirone, gepirone, ipsapirone and tandospirone, against motion sickness were investigated in Suncus murinus. Subcutaneous injection of all six agonists completely and dose-dependently suppressed motion-induced emesis. Pretreatment with 8-OH-DPAT or SUN8399 dose-dependently inhibited emesis elicited by nicotine (4.0 mg/kg, s.c.), veratrine (0.7 mg/kg, s.c.), cisplatin (20 mg/kg, i.p.) and copper sulfate (40 mg/kg, p.o.). These results suggest that serotonergic 5-HT1A-receptor agonists are effective as anti-motion sickness drugs, and these drugs may block a common mechanism(s) for the emetic reflex of the suncus because the antiemetic effects of the 5-HT1A-receptor agonists were exerted irrespective of the stimulus.

【 授权许可】

Unknown