Pharmacological Properties of Blood Pressure and Heart Rate Control in Suncus

The Japanese Journal of Pharmacology

Yuri Sakuma¹  Hiroshi Saito¹  Norio Matsuki¹ 

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

关键词: Blood pressure control;    Species-dependent difference;    Vagus reflex;    Suncus;   

DOI  :  10.1254/jjp.62.93

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(20)Cited-By(6)Blood pressure and heart rate and responses to various physiological substances in suncus were characterized and compared with those in mice. The blood pressures of the two species were similar, but the heart rate of suncus (about 400 beat/min) was significantly lower than that of mice. Norepinephrine increased the blood pressure but decreased the heart rate in suncus. The latter was blocked by cervical vagotomy. Sensitivities to acetylcholine and isoproterenol were lower in suncus. These results suggest that regulation of blood pressure and heart rate in suncus is very unique and different from the well-defined system of the rodents.

【 授权许可】

Unknown