Serotonin-Independent Model of Cisplatin-Induced Emesis in the Ferret

The Japanese Journal of Pharmacology

John A. Rudd¹  Celine H.K. Cheng²  Robert J. Naylor² 

[1] Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong;Postgraduate Studies in Pharmacology, The School of Pharmacy, University of Bradford

关键词: Cisplatin;    Emesis;    p-Chlorophenylalanine;    Ferret;    Delayed;   

DOI  :  10.1254/jjp.78.253

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(36)Cited-By(4)para-Chlorophenylalanine (PCPA, 100 - 200 mg/kg) was used as a pharmacological tool to characterize the 5-hydroxytryptamine (5-HT) involvement in the emesis occurring 24 hr after the administration of cisplatin (10 mg/kg) in the ferret. PCPA was effective to antagonize the initial 8 hr period of retching and vomiting, but potentiated the emesis that occurred during the remaining 8- to 24-hr observation period. Tissue samples removed from the brainstem at 24 hr post injection of cisplatin alone revealed an elevation of 5-HT, dopamine and homovanillic acid that was antagonized by the injection of PCPA. Cisplatin also induced increases in the urinary levels of 5-hydroxyindoleacetic acid that was similarly antagonized by PCPA. Results are discussed in terms of the relevance of 5-HT to the model of cisplatin (10 mg/kg)-induced emesis in the ferret compared to the problem of acute and delayed emesis in man. The residual or delayed phase of cisplatin-induced emesis may involve a 5-HT-independent mechanism.

【 授权许可】

Unknown