Blockade by Ginseng Extract of the Development of Reverse Tolerance to the Ambulation-Accelerating Effect of Methamphetamine in Mice

The Japanese Journal of Pharmacology

Masakatsu Takahashi¹  Hiroshi Kaneto¹  Shogo Tokuyama¹  Hack-Seang Kim²  Ki-Wan Oh² 

[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University;Department of Pharmacology, College of Pharmacy, Chungbuk National University

关键词: Ginseng;    Methamphetamine;    Reverse tolerance;   

DOI  :  10.1254/jjp.59.423

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(10)Cited-By(21)Daily repeated administration of methamphetamine (MAP) developed reverse tolerance to its ambulation-accelerating effect. After pretreatment of mice daily with ginseng extract (GE) for 5 days, concomitant injections of MAP and GE suppressed the development of reverse tolerance to the effect of MAP, although GE itself did not affect the spontaneous motor activity of the naive mice. These results provide evidence that GE may be useful for prevention and therapy of the adverse action of MAP.

【 授权许可】

Unknown