The Repeated Administration of Ketamine Induces an Enhancement of Its Stimulant Action in Mice

The Japanese Journal of Pharmacology

Hisashi Kuribara²  Toshihiro Morita¹  Tatsushi Fujita¹  Yoshitaka Uchihashi² 

[1] Department of Anesthesiology and Resuscitology, Gunma University School of Medicine;Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine

关键词: Ambulatory activity;    Ketamine;    Reverse tolerance;   

DOI  :  10.1254/jjp.61.149

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(9)The modification of the stimulant and motor-incoordinate actions of ketamine induced by repeated administration was investigated by means of ambulatory activity and rota-rod performance in mice, respectively. Ketamine (12.5, 25 and 50 mg/kg, s.c.)increased the mouse''s ambulation in a dosedependent manner, and the repeated 5-times administration at 3 to 4-day intervals enhanced the increment effect. However, a disruption of the rota-rod performance by ketamine was not modified by the repeated treatment. These results suggest that a reverse tolerance to the stimulant action of ketamine is produced, and that a tolerance to its motor-incoordinate action may not cause the enhancement.

【 授权许可】

Unknown