Cholesteryl Glucoside-induced Protection against Gastric Ulcer

Cell Structure and Function

Kimiko Murakami-Murofushi²  Narie Sasaki²  Hiromu Murofushi³  Tetsuyuki Kobayashi²  Shohko Kunimoto²  Wataru Murofushi²  Isao Yamatsu⁴  Yukie Hasegawa²  Susumu Kobayashi¹ 

[1] Faculty of Pharmaceutical Sciences, Science University of Tokyo;Department of Biology, Faculty of Science, Ochanomizu University;Department of Biophysics and Biochemistry, Graduate School of the University of Tokyo;Serendip Institute

关键词: steryl glucoside;    stress response;    heat shock protein;    heat shock factor;    anti-stress reagent;   

DOI  :  10.1247/csf.28.179

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(39)Cited-By(13)The cytoprotective effect of heat shock proteins (HSPs) promises new therapeutic modalities for medical treatment. We examined the anti-ulcer effect of cholesteryl glucoside (1-O-cholesteryl-β-D-glucopyranoside, CG) on cold-restraint stress-induced gastric ulcer in rats, in terms of its correlative ability to activate heat shock factor (HSF) and to induce HSP70. Rapid induction of CG occurred in animal tissues, especially in stomach, after exposure to stress, indicating that this glycolipid might act as an anti-stress, lipid mediator involved in the very early stages of stress-induced signal transduction. Orally administered CG apparently showed anti-ulcer activity in rats via HSF activation and HSP70 induction. When compared with geranylgeranylacetone (GGA), the well known as an effective, synthetic anti-ulcer agent, CG proved to have the same level of strength on ulcer inhibition. GGA caused CG and HSP70 induction in gastric mucosa, indicating that GGA induced HSP70 via CG production. CG thus might be useful for medical treatment of stress-induced diseases, and as an anti-stress supplement for daily diet.

【 授权许可】

Unknown