DE-FG02-04ER63746 FinalTechnicalReport

Lidstrom, M.E.

关键词: BIOLOGY;    FASTING;    GENES;    MUTANTS;    PHOSPHATES;    SOLVENTS;    STRAINS;    STRESSES;    WASTE PROCESSING;    WASTES Deinococcus;    stress response;    environmental remediation;   

DOI  :  10.2172/963660
RP-ID  :  DOE ER63746-1
PID  :  OSTI ID: 963660
Others  :  TRN: US201001%%578

学科分类：生物科学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

This is the final technical report for a project involving the study of stress response systems in the radiation-resistant bacterium, Deinococcus radiodurans. Three stresses of importance for a mixed waste treatment strain were studied, heat shock, solvent shock, and phosphate starvation. In each case, specific genes involved in the ability to survive the stress were identified using a systems biology approach, and analysis of mutants was used to understand mechanisms. This study has led to increased understanding of the ways in which a potential treatment strain could be manipulated to survive multiple stresses for treatment of mixed wastes.